|
KMID : 0670820150200040083
|
|
Korean Journal of Medical Mycology
2015 Volume.20 No. 4 p.83 ~ p.92
|
|
|
Analysis of Clinical Manifestations and Risk Factors for Treatment Failure in Fungal Keratitis
|
|
Lee Dong-Hyun
Ko Hyun-Chang
Lee Ji-Eun
|
|
|
Abstract
|
|
|
Background: Fungal keratitis is common cause of corneal infection. If not diagnosed and treated promptly and effectively, significant damage can occur.
Objective: To investigate the clinical manifestations and risk factors for treatment failure in fungal keratitis.
Methods: A total of 23 patients with fungal keratitis, who were diagnosed by clinical findings, smears, and cultures and followed up for at least 6 months, were studied retrospectively. Age, sex, previous history of trauma, corticosteroid use, previous ocular disease and surgery, systemic diseases, causative organism, features of keratitis, and treatment results were reviewed. A logistic regression analysis was performed to identify the prognostic risk factors.
Results: Thirteen patients (57%) were male and mean age was 57 ± 18 years. Trauma with vegetable matter (30%) was most commonly noted. The causative organisms were identified in 18 eyes (78%) and Aspergillus sp. (7 eyes, 30%) was the most common detected followed by Candida sp. (6 eyes, 26%), Fusarium sp. (3 eyes, 13%) and Penicillium sp. (2 eyes, 9%). A lesion located in the central area was 13 eyes (57%) and exceeding 10 mm2 in size was 15 eyes (65%). Hypopyon was found in 7 eyes (30%). Treatment failed in 9 eyes (39%), and predictor of treatment failure was a lesion exceeding10 mm2 (p < 0.05).
Conclusions: Risk factor for treatment failure included a large lesion size. Therefore, an effort should be made to discern the clinical features of fungal keratitis and to determine appropriate early treatment for a successful treatment outcome.
|
|
|
KEYWORD
|
|
|
Clinical manifestation, Fungal keratitis, Risk factor, Treatment failure
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|